After four doses of ipilimumab, restaging showed progressive disease in both intra- and extra-cranial sites. A large brain metastasis was resected and an induction regimen of fotemustine was commenced, but by February 2014 the patient had developed progressive microcyticanemia and a CT scan demonstrated three new bowel metastases...At this time, in April2014, a PPFIBP2-BRAFfusion was discovered in DNA extracted from a resected brain metastasis...