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Association details:
| Biomarker: | POU2F3 expression |
|---|---|
| Cancer: | Small Cell Lung Cancer |
| Drug: | barasertib (AZD1152) (Aurora kinase B inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
EP14.02-004 Barasertib Inhibits the Growth of SCLC Cell Lines and Transformed SCLC Patient Derived Model In Vitro and In Viv
Published date:
07/12/2022
Excerpt:
Barasertib showed anti-proliferative activity against POU2F3 positive SCLC cell lines as well as the PDC in dose-dependent manner….Collectively, these data support that targeting aurora kinase with barasertib efficiently suppresses the growth of SCLC-P subtype cells and the PDC.
