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Association details:
| Biomarker: | POLR1D amplification |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Avastin (bevacizumab) (VEGF-A inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer
Published date:
02/22/2020
Excerpt:
...we observed that the amplification and expression of one gene, POLR1D, impacted cell proliferation and resulted in upregulation of VEGFA, an important regulator of angiogenesis which has been implicated in the resistance to bevacizumab treatment….As this may result in the acquired resistance to bevacizumab, POLR1D is a potential therapeutic target for mCRC.
DOI:
10.1186/s13073-020-0719-6