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Association details:
| Biomarker: | PLCD1 deleltion |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | PD-L1 inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Comprehensive Genomic Profiling Identifies Novel Genetic Predictors of Response to Anti–PD-(L)1 Therapies in Non–Small Cell Lung Cancer
Excerpt:
At the focal level, we found that loss of tumor-suppressor genes, such as integrin α9 (ITGA9) and phospholipase Cδ1 (PLCD1), were among the top individual CNA events that significantly correlated with a worse outcome following anti–PD-(L)1 treatment.
DOI:
10.1158/1078-0432.CCR-19-0585