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    Association details:
    Biomarker:PKD1 mutation
    Cancer:Triple Negative Breast Cancer
    Drug:AiRuiKa (camrelizumab) (PD1 inhibitor) +
    famitinib (SHR 1020) (Multi-tyrosine kinase inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    Mol Cancer
    Title:

    Combined angiogenesis and PD-1 inhibition for immunomodulatory TNBC: concept exploration and biomarker analysis in the FUTURE-C-Plus trial

    Published date:
    03/25/2022
    Excerpt:
    We conducted the phase II FUTURE-C-Plus trial to assess the feasibility of combining famitinib (an angiogenesis inhibitor), camrelizumab (a PD-1 monoclonal antibody) and chemotherapy in advanced immunomodulatory TNBC patients...Within 48 enrolled patients, the objective response rate was 81.3% (95% CI, 70.2-92.3), and the median progression-free survival was 13.6 months (95% CI, 8.4-18.8)...Patients with CD8 and/or PD-L1- positive tumors benefit more from this regimen. PKD1 somatic mutation indicates worse progression-free and overall survival.
    Secondary therapy:
    albumin-bound paclitaxel
    DOI:
    10.1186/s12943-022-01536-6
    Trial ID:
    FUTURE-C-PLUS