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    Association details:
    Biomarker:PIK3CG expression
    Cancer:Melanoma
    Drug:Copiktra (duvelisib) (PI3Kδ inhibitor, PI3Kγ inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    AACR-II 2020
    Title:

    Abstract 663: The dual PI3K-d/PI3K-? inhibitor duvelisib inhibits signaling and proliferation of solid tumor cells expressing PI3K-d and/or PI3K-?

    Published date:
    05/15/2020
    Excerpt:
    To assess possible direct effects of duvelisib on solid tumor cells, the growth inhibitory activity of duvelisib was evaluated across 7 melanoma and 3 HNSCC cell lines expressing high levels of PI3K-δ and/or PI3K-γ....duvelisib can also directly inhibit signaling and proliferation of solid tumor cells expressing PI3K-δ and/or PI3K-γ, providing further rationale for clinical investigation of duvelisib for the treatment of solid tumors.
    DOI:
    10.1158/1538-7445.AM2020-663