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Association details:
| Biomarker: | PIK3CD overexpression |
|---|---|
| Cancer: | Melanoma |
| Drug: | Copiktra (duvelisib) (PI3Kδ inhibitor, PI3Kγ inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 663: The dual PI3K-d/PI3K-? inhibitor duvelisib inhibits signaling and proliferation of solid tumor cells expressing PI3K-d and/or PI3K-?
Published date:
06/23/2020
Excerpt:
...we used the GEPIA webserver to analyze the expression of PIK3CD [PI3K-δ] and PIK3CG [PI3K-γ] from the TCGA database...Further, PIK3CD was more highly expressed in melanoma and HNSCC human tumor samples compared to adjacent normal tissue....Duvelisib showed strong anti-proliferative activity (50-100% GI) in 3 out of 7 melanoma cell lines and 1 out of 3 HNSCC cell lines, and moderate activity (15-50% GI) in 3 melanoma cell lines and an additional HNSCC cell line.
DOI:
10.1158/1538-7445.AM2020-663
