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Association details:
| Biomarker: | PIK3CD expression |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | Copiktra (duvelisib) (PI3Kδ inhibitor, PI3Kγ inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 663: The dual PI3K-d/PI3K-? inhibitor duvelisib inhibits signaling and proliferation of solid tumor cells expressing PI3K-d and/or PI3K-?
Published date:
05/15/2020
Excerpt:
To assess possible direct effects of duvelisib on solid tumor cells, the growth inhibitory activity of duvelisib was evaluated across 7 melanoma and 3 HNSCC cell lines expressing high levels of PI3K-δ and/or PI3K-γ....duvelisib can also directly inhibit signaling and proliferation of solid tumor cells expressing PI3K-δ and/or PI3K-γ, providing further rationale for clinical investigation of duvelisib for the treatment of solid tumors.
DOI:
10.1158/1538-7445.AM2020-663
