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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

Synergistic and Antagonistic Antiproliferative Effects of Ribociclib (Lee011) and Irinotecan (SN38) on Colorectal Cancer Cells

Published date:
05/05/2023
Excerpt:
The combination of LEE011 and SN38 elicited a synergistic antiproliferative effect on HT-29 (PIK3CAP449T mutation) cells, and an antagonistic antiproliferative effect on SW480 (KRASG12V mutation) cells….The effects of the combination of LEE011 and conventional chemotherapy drugs on CRC depend on the chemotherapy drug and the specific gene mutation harbored by tumor cells.
Secondary therapy:
irinotecan
DOI:
10.21873/anticanres.16353