^
Association details:
Evidence:
Evidence Level:
Resistant: D – Preclinical
New
Title:

MEK inhibitor PD-0325901 overcomes resistance to PI3K/mTOR inhibitor PF-5212384 and potentiates anti-tumor effects in human head and neck squamous cell carcinoma

Excerpt:
PI3K/mTOR inhibitor PF-384 exhibits variable activity in a panel of HNSCC cell lines with differing PIK3CA expression and mutation status….Sensitivity (lower IC50) for PF-384 was significantly correlated with higher phosphorylation of AKT(T308/S473) (Fig. 2A,B), but not with PIK3CA overexpression (Fig 2C), or H1047R mutation alone (Fig. 1A).
DOI:
10.1158/1078-0432.CCR-14-3377