PI3K/mTOR inhibitor PF-384 exhibits variable activity in a panel of HNSCC cell lines with differing PIK3CA expression and mutation status….Sensitivity (lower IC50) for PF-384 was significantly correlated with higher phosphorylation of AKT(T308/S473) (Fig. 2A,B), but not with PIK3CA overexpression (Fig 2C), or H1047R mutation alone (Fig. 1A).