^
Association details:
Biomarker:PIK3CA K111N
Cancer:Breast Cancer
Drug:MEN1611 (PI3K inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic PIK3CA Mutations

Excerpt:
Daily oral administration of CH5132799 showed remarkable antitumor activity...Tumor regression was also observed in breast cancer BT-474 cells with the PIK3CA K111N mutation.
DOI:
10.1158/1078-0432.CCR-10-2882