^
Association details:
| Biomarker: | PIK3CA K111N |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | MEN1611 (PI3K inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic PIK3CA Mutations
Excerpt:
Daily oral administration of CH5132799 showed remarkable antitumor activity...Tumor regression was also observed in breast cancer BT-474 cells with the PIK3CA K111N mutation.
DOI:
10.1158/1078-0432.CCR-10-2882
