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Association details:
| Biomarker: | PIK3CA H1047R |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | PF-3845 (FAAH inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
MEK inhibitor PD-0325901 overcomes resistance to PI3K/mTOR inhibitor PF-5212384 and potentiates anti-tumor effects in human head and neck squamous cell carcinoma
Excerpt:
PI3K/mTOR inhibitor PF-384 exhibits variable activity in a panel of HNSCC cell lines with differing PIK3CA expression and mutation status….Sensitivity (lower IC50) for PF-384 was significantly correlated with higher phosphorylation of AKT(T308/S473) (Fig. 2A,B), but not with PIK3CA overexpression (Fig 2C), or H1047R mutation alone (Fig. 1A).
DOI:
10.1158/1078-0432.CCR-14-3377
