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Association details:
| Biomarker: | PIK3CA H1047R |
|---|---|
| Cancer: | Head and Neck Cancer |
| Drug: | Piqray (alpelisib) (PIK3CA inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
In Vitro Anticancer Activity of PI3K Alpha Selective Inhibitor BYL719 in Head and Neck Cancer
Excerpt:
Among the 6 HNSCC cell lines, SNU-1076 and Detroit562 have a PIK3CA H1047R mutation in exon 20….The PIK3CA-mutant cell lines (SNU-1076 and Detroit562) were more sensitive to BYL719 with a significant decrease in cell proliferation in a BYL719 dose-dependent manner than the PIK3CA wild-type cell lines (SNU-1066, SNU-1041, FaDu and SCC25)
