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Association details:
Biomarker:PIK3CA H1047R
Cancer:Colorectal Cancer
Drug:Erbitux (cetuximab) (EGFR inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Title:

PIK3CA Mutations Contribute to Acquired Cetuximab Resistance in Patients with Metastatic Colorectal Cancer

Excerpt:
Using circulating tumor DNA (ctDNA) from patients with mCRC and with acquired cetuximab resistance....Cell viability analysis suggested that in the presence of cetuximab in combination with 10 μmol/L 5-FU, compared with mock transfected cells, DiFi cells overexpressing p.K944N, p.V955G, p.V955I, p.K966E, p.E542K, p.E545K, and p.H1047R exhibited a high degree of resistance...These results demonstrate that these candidate mutations are likely to be involved in conferring resistance...
Secondary therapy:
5-fluorouracil
DOI:
10.1158/1078-0432.CCR-16-2738