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Association details:
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
New
Title:

Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib

Excerpt:
A 55-year-old woman presented with a large breast ulceration, biopsy specimen–diagnosed invasive ductal carcinoma (IDC), grade 3, ER+/PR+/HER2−…Tumor sequencing showed an activating PIK3CA mutation H1047R and amplification of PIK3C2B. Disease progressed after 4 months of treatment with fulvestrant and palbociclib.
Secondary therapy:
fulvestrant
DOI:
10.1200/PO.19.00403