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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

Targeting PI3K and PLK1 to Overcome Ibrutinib-Venetoclax Resistance in Mantle Cell Lymphoma

Excerpt:
All PI3K isoforms - α, β, γ and δ - are expressed in all the MCL cell lines tested...More interestingly, the combination of copanlisib and volasertib induced synergistic effects in ibrutinib-resistant, venetoclax-resistant, and ibrutinib-venetoclax dual-resistant cell lines in vitro. Moreover, combined treatment with copanlisib (6mg/kg/2d) and volasertib (5mg/kg/week) significantly enhanced anti-MCL activity in the same PDX model, compared to that of either single-agent treatment...
DOI:
https://doi.org/10.1182/blood-2019-128299