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Association details:
| Biomarker: | PIK3CA E110K |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | dactolisib (RTB101) (mTOR inhibitor, PI3K inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
Excerpt:
Another HNSCC patient-derived tumorgraft model (HPV-negative) harboring a PIK3CA mutation (E110K) was also found to be sensitive to BEZ-235 treatment...
DOI:
10.1158/2159-8290.CD-13-0103
