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Association details:
Biomarker:PHGDH overexpression
Cancer:Ovarian Cancer
Drug:cisplatin (DNA synthesis inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Title:

PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells

Published date:
06/10/2021
Excerpt:
Collectively, the current study described that PHGDH was upregulated and conferred resistance of ovarian cancer cells to cisplatin, suggesting that cisplatin resistance could be overcome by targeting PHGDH.
DOI:
10.3389/fonc.2021.643129