The study included 95 cases with the clinical diagnosis of locally advanced breast cancer...All of these cases had been treated with four cycles of adriamycin and cyclophosphamide (AC) chemotherapy….The 83 cases who showed pPR comprised maximum number 39 (47.0%) cases of HER2-positive type followed by 22 (26.5%) cases of ER-positive and/or PR positive and HER2-positive type and 16 (19.3%) cases of triple-negative type.