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    Association details:
    Biomarker:PGR expression
    Cancer:Breast Cancer
    Drug:Ibrance (palbociclib) (CDK4/6 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    Source:
    clinicaltrials.gov
    Title:

    Study Of Real-World Evidence In Patients Treated With Palbociclib During a 2.5 Years Follow-Up Period

    Excerpt:
    ...Documentation of histologically or cytologically confirmed diagnosis of breast cancer with IHC of estrogen receptor (ER) expression > 1% and/or progesterone receptor (PR) expression >1 % breast cancer based on local laboratory results....
    Trial ID:
    PALBO
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    Oncology
    Title:

    Evaluating the Response of Palbociclib on Progression-Free Survival in Hormone Receptor-Positive Metastatic Breast Cancer

    Published date:
    03/28/2022
    Excerpt:
    Seventy-six palbociclib-treated metastatic breast cancer patients were included in our study....In patients with PR ≥20%, median PFS was 25.0 months (lower 95% CI: 16.8 months; p = 0.0069)....Our study indicated that DR of palbociclib is frequently required but does not appear to affect PFS. PR expression was suggested to be a significant predictive factor for palbociclib responsiveness.
    DOI:
    10.1159/000524340