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    Association details:
    Biomarker:PER2 underexpression
    Cancer:Esophageal Squamous Cell Carcinoma
    Drug:cisplatin (DNA synthesis inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Biology (Basel)
    Title:

    PER2 Circadian Oscillation Sensitizes Esophageal Cancer Cells to Chemotherapy

    Published date:
    03/26/2021
    Excerpt:
    platin when PER2 expression is low enhances DNA damage and leads to a higher apoptosis rate.
    DOI:
    10.3390/biology10040266