^
Association details:
| Biomarker: | PER2 overexpression |
|---|---|
| Cancer: | Cervical Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Period circadian regulator 2 suppresses drug resistance to cisplatin by PI3K/AKT pathway and improves chronochemotherapeutic efficacy in cervical cancer
Published date:
10/11/2021
Excerpt:
Compared to cisplatin treatment at the lowest expression of PER2, tumor growth and proliferation of tumor cells were distinctly suppressed in mice treated with cisplatin at the highest expression of PER2.
DOI:
10.1016/j.gene.2021.146003