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Association details:
Biomarker:
PDZK1IP1 overexpression
Cancer:
Sarcoma
Drug:
Lynparza (olaparib)
(
PARP inhibitor
)
Direction:
Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Source:
Nature
Title:
Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment
Published date:
09/23/2020
Excerpt:
Higher MAP17 levels were only slightly associated with worse DFS (p = 0.047) and PFS (p = 0.05), with no relevance regarding OS.
DOI:
https://doi.org/10.1038/s41392-020-00246-z
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