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    Association details:
    Biomarker:PDGFRB overexpression
    Cancer:Melanoma
    Drug:Zelboraf (vemurafenib) (BRAF inhibitor, BRAF V600E inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Nature
    Title:

    Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

    Excerpt:
    We used PLX4032-resistant sub-lines artificially derived from B-RAF(V600E)-positive melanoma cell lines...Overexpression of PDGFRβ or N-RAS(Q61K) conferred PLX4032 resistance to PLX4032-sensitive parental cell lines.
    DOI:
    10.1038/nature09626