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Association details:
| Biomarker: | PDGFRA underexpression |
|---|---|
| Cancer: | Sarcoma |
| Drug: | pazopanib (Multi-tyrosine kinase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Relationship between PDGFR expression and the response to pazopanib in intimal sarcoma of the pulmonary artery: A case report
Published date:
11/09/2020
Excerpt:
The present study reports findings related to two cases of PAIS with PDGF and VEGF expression following treatment with pazopanib...In a second case with a weak expression of PDGFR-α and -β, the disease progressed rapidly on pazopanib (progression-free survival, 1.1 months)...The level of PDGFR expression in the tumor tissue may therefore be predictive of pazopanib efficacy.
DOI:
10.3892/mco.2020.2168
