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    Association details:
    Biomarker:PDGFRA rs2228230
    Cancer:Squamous Cell Carcinoma of Head and Neck
    Drug:cisplatin (DNA synthesis inhibitor) +
    5-fluorouracil (Thymidylate synthase inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    Cancers (Basel)
    Title:

    Germline Variants in Angiogenesis-Related Genes Contribute to Clinical Outcome in Head and Neck Squamous Cell Carcinoma

    Published date:
    04/06/2022
    Excerpt:
    ...we assessed the relationship between FGF/FGFR, PDGF/PDGFR, MMP, and TIMP genetic variants and treatment outcomes in HNSCC patients receiving radiotherapy (RT) alone or combined with cisplatin-based chemotherapy. In multivariate analysis, FGF2 rs1048201 CC homozygotes showed a higher risk of death (p = 0.039), while PDGFRA rs2228230 T was strongly associated with an increased risk of locoregional relapse (HR 2.49, p = 0.001) in the combination treatment subgroup.
    DOI:
    10.3390/cancers14071844