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Association details:
Evidence:
Evidence Level:
Sensitive: B - Late Trials
New
Title:

Biomarker Data From the Phase III KATHERINE Study of Adjuvant T-DM1 Versus Trastuzumab for Residual Invasive Disease After Neoadjuvant Therapy for HER2-Positive Breast Cancer

Published date:
02/02/2023
Excerpt:
In KATHERINE, adjuvant T-DM1 reduced risk of disease recurrence or death by 50% compared with trastuzumab in patients with residual invasive breast cancer...Low PD-L1 gene expression in residual disease was associated with worse outcomes with trastuzumab (HR, 0.66; 95% CI, 0.44–1.00), but not T-DM1 (HR, 1.05; 95% CI, 0.59–1.87).
DOI:
https://doi.org/10.1158/1078-0432.CCR-22-1989
Trial ID: