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Association details:
Biomarker:PD-L1 underexpression
Cancer:Esophageal Adenocarcinoma
Drug Class:Immunotherapy
Direction:Resistant
Evidence:
Evidence Level:
Resistant: B - Late Trials
Title:

Low Programmed Death-Ligand 1-Expressing Subgroup Outcomes of First-Line Immune Checkpoint Inhibitors in Gastric or Esophageal Adenocarcinoma

Published date:
02/01/2022
Excerpt:
These data suggest the lack of benefit in the addition of ICI to chemotherapy in low PD-L1-expressing GEAC tumors...our analyses fail to demonstrate a survival advantage offered by the addition of ICIs to conventional chemotherapy in patients with low PD-L1–expressing tumors.
Secondary therapy:
Chemotherapy
DOI:
10.1200/JCO.21.01862