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Association details:
| Biomarker: | PD-L1 overexpression + CD8 overexpression |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
PD-L1 Expression and CD8 Positive T Cell Tumor Infiltrate Level Predict Response to Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer
Published date:
02/22/2021
Excerpt:
In contrast, most responders displayed a high PD-L1 expression (mean TPS: 55.5%; range 1-100%) with most (7/8, 87.5%) having a high CD8 positive T-cell tumor infiltrate...However, a combination of high PD-L1 expression and high CD8 expression is much more accurate in determining response to ICI therapy and should be routinely assessed to assist in predicting response.
