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Association details:
| Biomarker: | PD-L1 negative |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | methotrexate (THF dehydrogenase inhibitor, Dihydrofolic acid reductase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Excerpt:
A summary of management strategies for recurrent and/or metastatic SCCHN...No platinum-based ChT during the last 6 months and PD-L1-negative tumour...Options...Methotrexate or taxane or cetuximab and/or BSC in case of contraindication to immunotherapy and unfit for platinum-based therapy...
