Response assessments included five complete and 15 partial responses, making the irRECIST RR 29% among the entire trial population...The median progression-free survival was 5.0 months, and the median overall survival was 24.7 months...Responses occurred in PD-L1–negative....prospective study in melanoma of pembrolizumab plus low-dose ipilimumab after anti-PD-1/L1 immunotherapy failure, demonstrating significant antitumor activity and tolerability.