Evidence Level:Sensitive: D – Preclinical
Title:
1017P - Preclinical evaluation of KD033, a human anti-PD-L1/IL-15 bispecific protein, in human PD-1/PD-L1 transgenic C57/Bl6 mice with PD-L1 positive and negative tumors
Excerpt:KD033 treatment resulted in significant tumor growth reduction in both h-PD-L1 positive and negative MC38 tumors….These results showed that the efficacy of anti-PD-L1-IL-15 fusion protein is not limited to PD-L1 tumor expression as KD033 was efficacious in both PD-L1 positive and negative tumors.