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    Association details:
    Biomarker:PD-L1 expression
    Cancer:Squamous Cell Carcinoma of Head and Neck
    Drug:methotrexate (THF dehydrogenase inhibitor, Dihydrofolic acid reductase inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: A2 - Guideline
    New
    Source:
    ESMO.org
    Title:

    Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNSeESMOeESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    Excerpt:
    A summary of management strategies for recurrent and/or metastatic SCCHN...No platinum-based ChT during the last 6 months and PD-L1-positive tumour...Options...Methotrexate or taxane or cetuximab and/or BSC if contraindication to immunotherapy and unfit for platinum-based therapy...