The median study follow-up time was 15.9 weeks (range 6.1-47.6). All 36 patients were efficacy evaluable; the confirmed ORR was 22.2% (95% confidence interval [CI]: 10.1, 39.2) and the unconfirmed ORR was 44.4% (95% CI: 27.9, 61.9). The DCR was 88.9% (95% CI: 73.9, 96.9). The confirmed ORR in PD-L1 TC ≥ 50% (n=13) was 23.1%, while the confirmed ORR in PD-L1 TC 1-49% (n=23) was 21.7%. The treatment combination of ociperlimab 900 mg plus tislelizumab 200 mg IV Q3W was well tolerated and showed antitumor activity in patients with treatment-naïve metastatic squamous or non-squamous NSCLC with PD-L1 positive tumors (TC ≥ 1%).