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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

EP08.02-128 Long Term Efficacy of SNK01 Plus Pembrolizumab for NSCLC: Expanded Observation from a Phase I/II A Randomized Controlled Trial

Published date:
07/12/2022
Excerpt:
This trial recruited 20 patients with advanced NSCLC with a PD-L1 tumor proportion score of 1% or greater who failed prior frontline platinum-based therapy were randomized to receive pembrolizumab with SNK01 (N=14) or pembrolizumab monotherapy(n=6)….The median PFS was 6.2 vs 1.7 months (Pembrolizumab + NK cells vs Pembrolizumab monotherapy), with significantly higher PFS by log-rank test [HR 0.15 95% CI: 0.05ᅳ0.53, p-value: 0.003]....this study shows that NK cells with pembrolizumab could be better than pembrolizumab alone for NSCLC.