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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma

Published date:
06/09/2021
Excerpt:
The efficacy evaluable population consisted of 89 patients from the phase II cohort with non-ocular melanoma who received indoximod combined with (P).The objective response rate (ORR) for the evaluable population was 51% with confirmed complete response of 20% and disease control rate of 70%. Median progression-free survival was 12.4 months (95% CI 6.4 to 24.9). The ORR for Programmed Death-Ligand 1 (PD-L1)-positive patients was 70% compared with 46% for PD-L1-negative patients...the combination of indoximod and (P) was well tolerated and showed antitumor efficacy...
DOI:
10.1136/jitc-2020-002057