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Association details:
Evidence:
Evidence Level:
Sensitive: A2 - Guideline
New
Source:
Excerpt:
Targeted therapy or immunotherapy for advanced or metastatic disease...PD-L1≥1%...first-line therapy...Carboplatin/albumin-bound paclitaxel/ atezolizumab (nonsquamous)
Secondary therapy:
carboplatin + albumin-bound paclitaxel
Evidence Level:
Sensitive: B - Late Trials
Source:
Title:

IMpower130: Progression-free survival (PFS) and safety analysis from a randomised phase III study of carboplatin + nab-paclitaxel (CnP) with or without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC

Published date:
10/01/2018
Excerpt:
PFS and OS benefit was observed in all PD-L1 subgroups, and consistently across all subgroups….IMpower130 showed statistically significant, clinically meaningful improvements in OS and statistically significant improvements in PFS with atezo + CnP, vs CnP, in 1L, stage IV non-squamous NSCLC...
Secondary therapy:
carboplatin + albumin-bound paclitaxel
DOI:
10.1093/annonc/mdy424.065
Trial ID:
Evidence Level:
Sensitive: C1 - Off-label
  (Approved for Non Small Cell Lung Cancer)
New
Title:

Chugai’s Tecentriq Obtains Regulatory Approval as the First Immunotherapy in Japan for Adjuvant Treatment of Non-small Cell Lung Cancer

Excerpt:
Chugai Pharmaceutical...announced that it obtained regulatory approval for an additional indication of the anti-cancer agent/humanized anti-PD-L1 monoclonal antibody Tecentriq® Intravenous Infusion 1200 mg [generic name: atezolizumab (genetical recombination)] for the adjuvant treatment of PD-L1-positive non-small cell lung cancer (NSCLC) from the Ministry of Health, Labour and Welfare....VENTANA OptiView PD-L1 (SP263), a pathological testing kit marketed by Roche Diagnostics K.K., should be used to detect PD-L1 expression.
Evidence Level:
Sensitive: C2 – Inclusion Criteria
New
Go to data
Title:

A Study of Atezolizumab in Combination With Carboplatin Plus (+) Nab-Paclitaxel Compared With Carboplatin+Nab-Paclitaxel in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Excerpt:
...PFS as Determined by the Investigator Using Recist v1.1 in the ITT Population, PD-L1 Expression Population, and PD-L1 Expression WT Population`OS as Determined by the Investigator Using Recist v1.1 in the ITT Population`OS as Determined by the Investigator Using RECIST v1.1 in the PD-L1 Expression Population and PD-L1 Expression WT Population`Percentage of Participants With an Objective Response (OR) (Complete Response [CR] or Partial Response [PR]) as Determined by the Investigator Using RECIST v1.1 in the ITT-WT Population`Percentage of Participants With an Objective Response (OR) (Complete Response [CR] or Partial Response [PR]) as Determined by the Investigator Using RECIST v1.1 in the ITT Population, PD-L1 Expression Population, and PD-L1 Expression WT Population`Duration of Response (DOR) as Determined by the Investigator Using RECIST v1.1 in ITT-WT Population, ITT Population, and PD-L1 Expression Population and PD-L1 Expression WT Population`Event Free Rate (%) at Year 1 and 2 in ITT-WT Population and ITT Population`Event Free Rate (%) at Year 1 and 2 in PD-L1 Expression Population and PD-L1 Expression WT Population`Time to Deterioration (TTD) in Patient-Reported Lung Cancer Symptoms in the ITT-WT Population`Change From Baseline in Patient-Reported Lung Cancer Symptoms Score Using the Symptoms in Lung Cancer (SILC) Scale`Percentage of Participants With Adverse Events`Percentage of Participants With Anti-Therapeutic Antibodies (ATAs) to Atezolizumab`Maximum Observed Serum Concentration (Cmax) of Atezolizumab for Patients in Atezolizumab+Carboplatin+Nab-Paclitaxel Arm`Minimum Observed Serum Concentration (Cmin) of Atezolizumab Prior to Infusion in Atezolizumab+Carboplain+Nab-Paclitaxel`Plasma Concentrations of Carboplatin`Plasma Concentrations of Nab-Paclitaxel Reported as Total Paclitaxel...
Trial ID:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
New
Title:

A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice

Excerpt:
...Patients with EGFR activating mutations or ALK- positive tumour mutations should also have received targeted therapy (Cohort 3 LOT1 NSCLC) or (4) In combination with carboplatin and etoposide, is indicated for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC) (Cohort 4 LOT1 ES-SCLC) or (5) As a monotherapy, for the treatment of metastatic NSCLC with high PD-L1 expression, previously untreated (Cohort 5 LOT1 NSCLC) or (6) In combination with bevacizumab for unresectable locally advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy (Cohort 6 LOT1 HCC) ....
Trial ID:
More C2 evidence
Evidence Level:
Sensitive: C2 – Inclusion Criteria
New
Title:

A Study of Atezolizumab (MPDL3280A) Compared With a Platinum Agent (Cisplatin or Carboplatin) + (Pemetrexed or Gemcitabine) in Participants With Stage IV Non-Squamous or Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower110]

Excerpt:
...- Tumor PD-L1 expression as determined by immunohistochemistry (IHC) assay of archival tumor tissue or tissue obtained at screening...
Trial ID:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
New
Title:

Evaluating the Efficacy of Atezolizumab in Advanced Non-small Cell Lung Cancer (NSCLC)

Excerpt:
...- Willingness to undergo a biopsy ≤ 6 weeks of the start of study treatment to obtain formalin-fixed paraffin-embedded tumor specimens in paraffin blocks (blocks are preferred) or at least 15 unstained slides, with an associated pathology report, for central testing of tumor PD-L1 expression....
Trial ID:
Less C2 evidence
Evidence Level:
Sensitive: C3 – Early Trials
Title:

Carboplatin and nab-paclitaxel chemotherapy with or without atezolizumab as front-line management for treatment-naïve metastatic nonsquamous non-small cell lung cancer with PD-L1 staining: a retrospective study

Published date:
01/01/2022
Excerpt:
The objective response rate of 53.3% (95% CI 45.1–57.8) in the ACN group was higher than the 29.7% (26.1–32.8) observed in the CN group (p = 0.008) (Table 2). For patients in the ACN group, the ORR was 11.7%, 18.3%, and 23.3% for cohorts TC1, TC2, and TC3, respectively....Subgroup analyses demonstrated that for individuals with TC3 PD-L1-expressing cells, the median OS was 23.7 months in the ACN group versus 16.1 months in the CN group (HR 0.25; p = 0.001)....The findings of this study demonstrate that the atezolizumab plus carboplatin and nab-paclitaxel regimen as front-line management might provide greater survival benefits in PD-L1-positive metastatic nonsquamous NSCLC patients in a selected population than the carboplatin and nab-paclitaxel regimen, with a tolerable safety profile.
Secondary therapy:
carboplatin + albumin-bound paclitaxel
DOI:
https://doi.org/10.1007/s00432-021-03873-3