Keytruda as monotherapy is indicated for the first line treatment of metastatic non small cell lung carcinoma in adults whose tumours express PD L1 with a ≥ 50% tumour proportion score (TPS) with no EGFR or ALK positive tumour mutations.

We conducted a multicenter single arm phase II trial in pts with classic/endemic KS with cutaneous extension requiring systemic treatment. Pts were treated with pembrolizumab (pembro) 200mg every 3 weeks for 6 months….On baseline tumor samples, the lack of PDL1 expression on tumor and immune cells was associated with poor efficacy of pembro....In the first prospective trial assessing the role of PD1 blockade in classic/endemic KS, pembro showed efficacy with 12 out of 16 of pts having CR or PR (BORR above 30%) and had an acceptable safety profile.