...The secondary endpoints are the rate of objective response, disease control, duration of response and time to progression based on RECIST criteria v 1.1, as well as the pattern of progression and overall survival (OS).Exploratory endpoints are: • PD-1 and PD-L1 expression in tumor samples, TILs density, inflammatory blood markers.• ALBI score at baseline and time to progression untreatable by locoregional therapies. ...