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Association details:
Evidence:
Evidence Level:
Sensitive: C1 - Off-label
  (Approved for Non Small Cell Lung Cancer)
New
Title:

Chugai’s Tecentriq Obtains Regulatory Approval as the First Immunotherapy in Japan for Adjuvant Treatment of Non-small Cell Lung Cancer

Excerpt:
Chugai Pharmaceutical...announced that it obtained regulatory approval for an additional indication of the anti-cancer agent/humanized anti-PD-L1 monoclonal antibody Tecentriq® Intravenous Infusion 1200 mg [generic name: atezolizumab (genetical recombination)] for the adjuvant treatment of PD-L1-positive non-small cell lung cancer (NSCLC) from the Ministry of Health, Labour and Welfare....VENTANA OptiView PD-L1 (SP263), a pathological testing kit marketed by Roche Diagnostics K.K., should be used to detect PD-L1 expression.
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

1211P - A multicenter phase II study of atezolizumab monotherapy following definitive chemoradiotherapy for unresectable locally advanced esophageal squamous cell carcinoma (EPOC1802)

Published date:
09/05/2022
Excerpt:
We investigated the efficacy and safety of 1-year atezolizumab treatment following 60 Gy of dCRT in patients with unresectable locally advanced ESCC....In 35 patients with an evaluable PD-L1 tumor proportion score, the cCR rates of <1% and ≥1% were 44.4% and 41.2%, respectively. Multiplexed immunohistochemistry of 38 evaluable patients indicated significantly higher tumor-infiltrating CD8+ T cells and PD-1+CD8+ T cells before dCRT in 15 patients with cCR than in 23 without cCR (p=0.0002 and 0.0020, respectively)....Atezolizumab monotherapy following dCRT resulted in a promising cCR rate and led to promising long-term survival. Tumor-infiltrating CD8+ T cells and PD-1+CD8+ T cells can serve as biomarkers for cCR.