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Association details:
| Biomarker: | PD-L1 expression |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | SAR445710 (PD-L1 inhibitor, IL-15R stimulant) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1017P - Preclinical evaluation of KD033, a human anti-PD-L1/IL-15 bispecific protein, in human PD-1/PD-L1 transgenic C57/Bl6 mice with PD-L1 positive and negative tumors
Published date:
09/13/2021
Excerpt:
KD033 treatment resulted in significant tumor growth reduction in both h-PD-L1 positive and negative MC38 tumors….These results showed that the efficacy of anti-PD-L1-IL-15 fusion protein is not limited to PD-L1 tumor expression as KD033 was efficacious in both PD-L1 positive and negative tumors.
