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Association details:
| Biomarker: | PD-L1 expression |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | Opal (PD1 inhibitor, CD137 agonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2076 / 14 - Opal is a conditional 4-1BB agonistic fusion protein comprising trimerized 4-1BB ligand and a high affinity variant of the extracellular domain of PD-1
Published date:
03/09/2022
Excerpt:
To evaluate the efficacy and toxicity of Opal in vivo, MC38 tumor cells expressing human PDL1 were inoculated in the flanks of mice expressing human 4-1BB. When tumor-bearing mice were treated IP with Opal at 1 mg/kg, 7/10 mice exhibited durable cures without significant body weight loss.
