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Association details:
Biomarker:PD-L1 expression
Cancer:Colon Cancer
Drug:CCX559 (PD-L1 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

5693 - Anti-tumor effect of orally available small molecule PD-L1 inhibitors in a murine model of colon adenocarcinoma

Published date:
06/24/2020
Excerpt:
Due to the specific reactivity of these compounds to human PD-L1 (but not murine PD-L1), a syngeneic tumor model with murine MC-38 colon tumor cells expressing human PD-L1 (MC38-hPD-L1 tumor model) was used. In the MC38-hPD-L1 tumor model, Lead compounds potently reduced tumor growth similarly to an anti-human PD-L1 antibody, which was used as a positive control for the experiments....and potent anti-tumor effects in an animal model.