...• Duration of freedom from clinical relapse in Study Subjects showing decrease or stabilization of ctDNA level after treatment with investigational agent• Overall survival after cystectomy in Study Subjects having biochemical relapse• Cancer specific survival after cystectomy in Study Subjects having biochemical relapse• Recurrence free survival after cystectomy in Study Subjects having biochemical relapse• Cancer specific survival after cystectomy in Study Subjects having biochemical relapse stratified for potential predictive biomarkers for response to treatment• Response rate to investigated agent stratified for PD-L1 expression and other predictive biomarkers like TMB, immune cell infiltration, tumor subtypes etc.• Response rate to neoadjuvant chemotherapy measured as down staging to T0 or T<2 at cystectomy and correlation with level of ctDNA in plasma and urine samples• Time to recurrence seen on imaging (symptomatic or asymptomatic)• Quality of life assessment using the EORTC QLQ 30 (Quality of life in cancer patients) and QLQ-BLM30 (Quality of life in patients with Muscle Invasive Bladder Cancer)• Cost-effectiveness modelling analysis• Prolonged CR defined as ctDNA negative status in the plasma samples taken 12 months following completion of IO combined with negative imaging (CT) at the same time point, without administration of other oncologic treatment Yderligere målepunkter omfatter langtidsoverlevelse, effekt af behandling samt vurdering af metoder til at forudsige effekt ud fra forskellige analyser, der kan laves på patientens svulstvæv....