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Association details:
| Biomarker: | PD-L1 deletion |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Resistant |
Evidence:
Source:
Title:
Genomic correlates of PD-L1 expression are associated with response to immunotherapy in non-small cell lung cancer
Published date:
04/28/2020
Excerpt:
STK11 mutation (Log-rank test, q=0.1), EGFR mutation (q<1e-3), and CN loss of PD-L1, PD-L2, and/or JAK2 (q=0.02) were all significantly associated with worse PFS after ICB. EGFR mutation was significantly associated with worse OS after ICB (q=0.19).
