^
Association details:
| Biomarker: | PD-L1 deletion + STK11 mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Resistant |
Evidence:
Source:
Title:
Genomic correlates of PD-L1 expression are associated with response to immunotherapy in non-small cell lung cancer
Published date:
04/28/2020
Excerpt:
We further show that they may indicate distinct subtypes of PD-L1 neg. tumors with STK11 mutant tumors exhibiting strikingly worse prognosis after ICB (med. PFS 52 vs 64 days, p<1e-3; med. OS 212 vs 299 days, p=5e-3). We further show that they may indicate distinct subtypes of PD-L1 neg. tumors with STK11 mutant tumors exhibiting strikingly worse prognosis after ICB (med. PFS 52 vs 64 days, p<1e-3; med. OS 212 vs 299 days, p=5e-3).
