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Association details:
| Biomarker: | PD-1 positive |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | Opdivo (nivolumab) (PD1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies
Published date:
03/01/2022
Excerpt:
On the contrary, NIVO promoted proliferation, reduced apoptosis, and protected PD-1+ cells from chemo/radiotherapy…. In vivo, NIVO promoted HT29 tumor growth,...In PD-1+ human colon cancer cells, NIVO activates tumor survival pathways and could protect tumor cells from conventional therapies.
DOI:
10.1136/jitc-2021-004032
