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    Association details:
    Biomarker:PCSK9 expression
    Cancer:Ovarian Cancer
    Drug:PF-06446846 (PCSK9 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Cancers (Basel)
    Title:

    Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors

    Published date:
    07/24/2021
    Excerpt:
    Targeting PCSK9 expression with siRNA or PCSK9 specific inhibitor (PF-06446846) impaired OC cell survival.
    DOI:
    10.3390/cancers13153727