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Association details:
| Biomarker: | PBRM1 negative |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug Class: | mTOR inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Comprehensive molecular and immunohistochemical analysis of advanced renal cell carcinoma patients treated with mTOR inhibitors.
Published date:
05/16/2018
Excerpt:
In the full series, negative IHC expression for BAP1 and PBRM1 was associated with better mTOR inhibitor response (OR = 4.0, 95%CI = 1.4-11.9, P = 0.011 and OR = 3.9, 95%CI = 1.2-12.8, P = 0.025, respectively, multivariable analysis)….Lack of BAP1 and PBRM1 expression was associated with improved response to mTOR inhibitors.
DOI:
10.1200/JCO.2018.36.15_suppl.4559
