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Association details:
| Biomarker: | PBRM1 mutation |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | PRT1419 (MCL1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
6147 / 9 - MCL1 inhibitor PRT1419 demonstrates anti-tumor activity in PBRM1-altered clear cell renal cancer and synergizes with standard of care agents
Published date:
03/15/2023
Excerpt:
We observed potent inhibition of tumor growth as well as induction of apoptosis by PRT1419 in various preclinical models of PBRM1-mutant ccRCC but not in PBRM1-WT tumor models.
